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Cover Picture: Intracellular uptake and inhibitory activity of aromatic fluorinated amino acids in human breast cancer cells (ChemMedChem 9/2008)
Author(s) -
Giese Christoph,
Lepthien Sandra,
Metzner Linda,
Brandsch Matthias,
Budisa Nediljko,
Lilie Hauke
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200890034
Subject(s) - amino acid , chemistry , aromatic amino acids , intracellular , human breast , biological activity , inhibitory postsynaptic potential , stereochemistry , cancer cell , biochemistry , in vitro , cancer , biology , endocrinology , genetics
The cover picture shows fluorinated aromatic amino acids that exhibit cytostatic activity on tumor cells. These amino acid derivatives are taken up by the cells via the amino acid transport system L. This active process results in a 70‐fold accumulation of the fluorinated aromatic amino acids within the cell relative to the surrounding media, which explains why they are biologically active with quite low EC 50 values. For details, see the Full Paper by N. Budisa, H. Lilie, et al. on p. 1449 ff.