Premium
Cover Picture: Rapid Identification of a Putative Interaction between β 2 ‐Adrenoreceptor Agonists and ATF4 using a Chemical Genomics Approach (ChemMedChem 5/2008)
Author(s) -
Ladwa Sweta R.,
Dilly Suzanne J.,
Clark Andrew J.,
Marsh Andrew,
Taylor Paul C.
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200890018
Subject(s) - chemistry , computational biology , structural genomics , genomics , dimer , nucleic acid , chemical space , crystallography , stereochemistry , biochemistry , biology , protein structure , drug discovery , gene , genome , organic chemistry
The cover picture shows a view from the X‐ray crystallographic structure of activating transcription factor, ATF4, showing its molecular surface in a coiled‐coil dimer with C/EBPβ, depicted in red. The interaction of the sequence highlighted in green with salbutamol is uncovered by S. R. Ladwa et al. on p. 742 ff. using the magic tag® chemical genomics approach. Key residues of the known DNA binding motif within this sequence are shown in space‐filling representation to highlight how salbutamol, also depicted, might approach and modulate interaction with the nucleic acid target.