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Design, Synthesis, and Biological Evaluation of Levoglucosenone‐Derived Ras Activation Inhibitors
Author(s) -
Müller Christian,
GomezZurita Frau Maria Antonia,
Ballinari Dario,
Colombo Sonia,
Bitto Alessandro,
Martegani Enzo,
Airoldi Cristina,
van Neuren Anske Stephanie,
Stein Matthias,
Weiser Jörg,
Battistini Carlo,
Peri Francesco
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800416
Subject(s) - chemistry , combinatorial chemistry , tricyclic , in vitro , cell culture , nucleotide , biochemistry , stereochemistry , computational biology , biology , genetics , gene
A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone‐derived scaffold with aromatic moieties. Some members of the panel show in vitro inhibitory activity toward the nucleotide exchange process on Ras and are toxic to some human cancer cell lines.