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Inhibition of Peroxidase‐Catalyzed Iodination by Cephalosporins: Metallo‐β‐Lactamase‐Induced Antithyroid Activity of Antibiotics
Author(s) -
Tamilselvi A.,
Mugesh Govindasamy
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800371
Subject(s) - antibiotics , cephalosporin , peroxidase , chemistry , ring (chemistry) , broad spectrum , catalysis , halogenation , hydrolysis , cephalosporin antibiotic , microbiology and biotechnology , enzyme , stereochemistry , biochemistry , combinatorial chemistry , organic chemistry , biology
Broad‐spectrum antibiotics with heterocyclic side chains strongly inhibit peroxidase‐catalyzed iodination in the presence of metallo‐β‐lactamase. This suggests that antibiotic resistance due to hydrolysis of the β‐lactam ring in antibiotics would have negative effects on thyroid activity.