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The Synthesis and in vivo Evaluation of 2′,2′‐Difluoro KRN7000
Author(s) -
Leung Leo,
Tomassi Cyrille,
Van Beneden Katrien,
Decruy Tine,
Trappeniers Matthias,
Elewaut Dirk,
Gao Yifang,
Elliott Tim,
AlShamkhani Aymen,
Ottensmeier Christian,
Werner Jörn M.,
Williams Anthony,
Van Calenbergh Serge,
Linclau Bruno
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800348
Subject(s) - cd1d , glycolipid , in vivo , t cell receptor , natural killer t cell , chemistry , microbiology and biotechnology , stereochemistry , in vitro , immunology , biochemistry , biology , t cell , cytotoxic t cell , immune system
The synthesis of 2′,2′‐difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d‐dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.