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Solute‐Binding Sites in ABC Transporters for Recognition, Occlusion and Trans‐Inhibition
Author(s) -
Parcej David,
Tampé Robert
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800328
Subject(s) - atp binding cassette transporter , context (archaeology) , transporter , mechanism (biology) , computational biology , transmembrane protein , biology , drug , chemistry , biochemistry , pharmacology , gene , receptor , physics , quantum mechanics , paleontology
Learning your ABC : ATP‐binding cassette (ABC) transporters play key roles in the transport of solutes into, and out of cells. These transmembrane proteins are discussed in the context of their importance as targets for both antitumor and antimicrobial agents, due to the crucial role in drug resistance. The structural differences of ABC systems, arising from the need of various classes of solutes, are described and pieced together with functional data to suggest a common mechanism.