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Differences in Paclitaxel and Docetaxel Interactions with Tubulin Detected by Mutagenesis of Yeast Tubulin
Author(s) -
Winefield Robert D.,
Entwistle Ruth A.,
Foland Travis B.,
Lushington Gerald H.,
Himes Richard H.
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800288
Subject(s) - paclitaxel , tubulin , docetaxel , benzamide , yeast , chemistry , mutagenesis , microtubule , biochemistry , stereochemistry , mutation , biology , genetics , chemotherapy , gene
A molecular model showing the yeast tubulin–paclitaxel and tubulin–docetaxel complexes in a mutated form of the protein that contains Asn at position 227 instead of His. The side chain of Asn 227 is able to form an H‐bond with the carbonyl oxygen of the paclitaxel benzamide and the docetaxel carbamate groups.