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Efficient Cellular Labeling by CD44 Receptor‐Mediated Uptake of Cationic Liposomes Functionalized with Hyaluronic Acid and Loaded with MRI Contrast Agents
Author(s) -
Esposito Giovanna,
Geninatti Crich Simonetta,
Aime Silvio
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800234
Subject(s) - hyaluronic acid , internalization , cationic polymerization , liposome , chemistry , cationic liposome , cd44 , receptor , biophysics , supramolecular chemistry , endosome , biochemistry , combinatorial chemistry , in vitro , polymer chemistry , organic chemistry , molecule , biology , transfection , anatomy , gene
The supramolecular adducts of negatively charged hyaluronic acid polymers and cationic Gd‐liposomes were used for labeling cells that overexpress CD44 receptors. This cellular labeling methodology is very efficient and allows the internalization of a large payload of soluble Gd complexes in a very short timeframe.