Enzymatic Release of a Surface‐Adsorbed RGD Therapeutic from a Cleavable Peptide Anchor | Zendy

Meyers Steven R. | Zendy; Kenan Daniel J. | Zendy; Grinstaff Mark W. | Zendy

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Enzymatic Release of a Surface‐Adsorbed RGD Therapeutic from a Cleavable Peptide Anchor

Author(s) -

Meyers Steven R.,

Kenan Daniel J.,

Grinstaff Mark W.

Publication year - 2008

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200800205

Subject(s) - peptide , drug delivery , adsorption , mechanism (biology) , enzyme , chemistry , medical device , nanotechnology , sequence (biology) , biochemistry , computational biology , combinatorial chemistry , computer science , medicine , materials science , biomedical engineering , biology , organic chemistry , physics , quantum mechanics

Implanted medical devices inevitably promote inflammation of the surrounding tissue. A method for enzymatically triggered localized drug delivery would have marked benefits in dealing with this response. Herein we present a rationally designed peptide coating for use with medical devices such as stents, that contains three distinct domains: 1) an implant‐adsorptive sequence, 2) an enzymatically cleavable release mechanism, and 3) a therapeutic to be delivered.

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