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Enzymatic Release of a Surface‐Adsorbed RGD Therapeutic from a Cleavable Peptide Anchor
Author(s) -
Meyers Steven R.,
Kenan Daniel J.,
Grinstaff Mark W.
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800205
Subject(s) - peptide , drug delivery , adsorption , mechanism (biology) , enzyme , chemistry , medical device , nanotechnology , sequence (biology) , biochemistry , computational biology , combinatorial chemistry , computer science , medicine , materials science , biomedical engineering , biology , organic chemistry , physics , quantum mechanics
Implanted medical devices inevitably promote inflammation of the surrounding tissue. A method for enzymatically triggered localized drug delivery would have marked benefits in dealing with this response. Herein we present a rationally designed peptide coating for use with medical devices such as stents, that contains three distinct domains: 1) an implant‐adsorptive sequence, 2) an enzymatically cleavable release mechanism, and 3) a therapeutic to be delivered.