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Necessity is the Mother of Invention: An Ingenious Method for Leukocyte‐Targeted Delivery of siRNA in Stabilized Nanoparticles Demonstrates a Role of Cyclin D1 in Inflammation
Author(s) -
Kakuta Hiroki
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800095
Subject(s) - gene silencing , cyclin d1 , small interfering rna , inflammation , nanoparticle , cyclin , microbiology and biotechnology , cancer research , nanotechnology , chemistry , medicine , biology , materials science , immunology , transfection , cell , cell cycle , biochemistry , gene
Leukocyte‐targeted delivery of siRNA in stabilized nanoparticles: This Highlight article summarizes elegantly designed targeted nanoparticles that can be administered systemically to deliver siRNA for cyclin D1 to specific leukocyte subsets. Silencing of cyclin D1 in this way can reverse experimentally induced colitis in mice.