Multi‐Receptor Binding Profile of Clozapine and Olanzapine: A Structural Study Based on the New β 2  Adrenergic Receptor Template | Zendy

Selent Jana | Zendy; López Laura | Zendy; Sanz Ferran | Zendy; Pastor Manuel | Zendy

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Multi‐Receptor Binding Profile of Clozapine and Olanzapine: A Structural Study Based on the New β 2 Adrenergic Receptor Template

Author(s) -

Selent Jana,

López Laura,

Sanz Ferran,

Pastor Manuel

Publication year - 2008

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200800074

Subject(s) - clozapine , olanzapine , receptor , schizophrenia (object oriented programming) , pharmacology , chemistry , computational biology , psychology , medicine , biochemistry , biology , psychiatry

The relationships between the multi‐receptor binding profile of clozapine and olanzapine and their therapeutic properties were analyzed by using novel complexes built from the recently solved β 2 adrenergic receptor structure. While interactions with position 3.36 determine the binding profile of clozapine‐like ligands, diversity in TM5 and TM6 is responsible for subtle differences between clozapine and olanzapine.

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