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Multi‐Receptor Binding Profile of Clozapine and Olanzapine: A Structural Study Based on the New β 2 Adrenergic Receptor Template
Author(s) -
Selent Jana,
López Laura,
Sanz Ferran,
Pastor Manuel
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800074
Subject(s) - clozapine , olanzapine , receptor , schizophrenia (object oriented programming) , pharmacology , chemistry , computational biology , psychology , medicine , biochemistry , biology , psychiatry
The relationships between the multi‐receptor binding profile of clozapine and olanzapine and their therapeutic properties were analyzed by using novel complexes built from the recently solved β 2 adrenergic receptor structure. While interactions with position 3.36 determine the binding profile of clozapine‐like ligands, diversity in TM5 and TM6 is responsible for subtle differences between clozapine and olanzapine.