Premium
Conjugation of ATIII‐Binding Pentasaccharides to Extend the Half‐Life of Proteins: Long‐Acting Insulin
Author(s) -
de Kort Martin,
Gianotten Bas,
Wisse Jeffry A. J.,
Bos Ebo S.,
Eppink Michel H. M.,
Mattaar Ellen,
Vogel Gerard M. T.,
Dokter Wim H. A.,
Honing Maarten,
Vonsovic Stanislava,
Smit MartinJan,
Wijkmans Jac C. H. M.,
van Boeckel Constant A. A.
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800053
Subject(s) - antithrombin , insulin , chemistry , action (physics) , duration (music) , biochemistry , computer science , computational biology , biology , endocrinology , art , heparin , physics , literature , quantum mechanics
CarboCarrier tm : Site‐specific conjugation of insulin to a synthetic antithrombin III (ATIII)‐binding pentasaccharide (PS) improves the protein's half‐life and extends the duration of action. The half‐life can be adjusted by changing the PS affinity for ATIII.