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Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors
Author(s) -
Ettari Roberta,
Nizi Emanuela,
Di Francesco Maria Emilia,
Micale Nicola,
Grasso Silvana,
Zappalà Maria,
Vičík Radim,
Schirmeister Tanja
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800050
Subject(s) - cysteine protease , cysteine , chemistry , stereochemistry , enzyme , protease , enzyme inhibitor , combinatorial chemistry , biochemistry
Antimalarials : The aim of our work was to investigate the ability of nonpeptidic vinyl and allyl phosphonates to inhibit falcipain‐2 (FP‐2), the main cysteine protease of P. falciparum. Some of the compounds synthesized, such as the one shown, moderately inhibit FP‐2 activity.