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Conjugation of Spermine Facilitates Cellular Uptake and Enhances Antitumor and Antibiotic Properties of Highly Lipophilic Porphyrins
Author(s) -
Hahn Frank,
Schmitz Katja,
Balaban Teodor S.,
Bräse Stefan,
Schepers Ute
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200800013
Subject(s) - porphyrin , moiety , photodynamic therapy , spermine , chemistry , combinatorial chemistry , solubility , polyamine , ring (chemistry) , biochemistry , stereochemistry , organic chemistry , enzyme
Photodynamic therapy : The application of porphyrins in photodynamic therapy has been limited by their low solubility and cellular uptake efficiency. The introduction of a charged polyamine moiety to the lipophilic porphyrin ring can enhance the amphiphilicity of a compound of this class and ultimately lead to greater therapeutic efficacy.