Conjugation of Spermine Facilitates Cellular Uptake and Enhances Antitumor and Antibiotic Properties of Highly Lipophilic Porphyrins | Zendy

Hahn Frank | Zendy; Schmitz Katja | Zendy; Balaban Teodor S. | Zendy; Bräse Stefan | Zendy; Schepers Ute | Zendy

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Conjugation of Spermine Facilitates Cellular Uptake and Enhances Antitumor and Antibiotic Properties of Highly Lipophilic Porphyrins

Author(s) -

Hahn Frank,

Schmitz Katja,

Balaban Teodor S.,

Bräse Stefan,

Schepers Ute

Publication year - 2008

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200800013

Subject(s) - porphyrin , moiety , photodynamic therapy , spermine , chemistry , combinatorial chemistry , solubility , polyamine , ring (chemistry) , biochemistry , stereochemistry , organic chemistry , enzyme

Photodynamic therapy : The application of porphyrins in photodynamic therapy has been limited by their low solubility and cellular uptake efficiency. The introduction of a charged polyamine moiety to the lipophilic porphyrin ring can enhance the amphiphilicity of a compound of this class and ultimately lead to greater therapeutic efficacy.

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