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Cover Picture: Light‐Directed Activation of Human T‐Cells / Light Activation of Anti‐CD3 in vivo Reduces the Growth of an Aggressive Ovarian Carcinoma (ChemMedChem 11/2007)
Author(s) -
Self Colin H.,
Self Alexander C.,
Smith Jacqueline A.,
Self David J.,
Thompson Stephen,
Stewart Robert
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200790037
Subject(s) - in vivo , cover (algebra) , cancer research , chemistry , cell growth , t cell , cell , cd3 , microbiology and biotechnology , immune system , biology , immunology , biochemistry , mechanical engineering , cd8 , engineering
The cover picture shows an impression of a photoactivatable bispecific antibody bound to a tumour. Only the antitumour portion is initially active, allowing tumour cell binding. On irradiation with UV light the T‐cell binding site is reactivated, allowing T‐cell binding and activation. As anti‐T‐cell activity is not reactivated outside of the illuminated treatment area, immune activation is highly specific targeted to tumour tissues. For details, see the two back‐to‐back Communications by C. H. Self, S. Thompson, et al. on pp. 1587 and 1591 ff. (BioTransformations Ltd. Image courtesy of the Centre for Design Research.)