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Cover Picture: Antimalarial Cation‐dimers Synthesized in Two Steps from an Inexpensive Starting Material, Isonicotinic Acid (ChemMedChem 10/2007)
Author(s) -
Motoshima Kazunori,
Hiwasa Yoshiko,
Yoshikawa Mai,
Fujimoto Kanji,
Tai Akihiro,
Kakuta Hiroki,
Sasaki Kenji
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200790033
Subject(s) - isonicotinic acid , malaria , cover (algebra) , cationic polymerization , combinatorial chemistry , chemistry , stereochemistry , nanotechnology , materials science , organic chemistry , biology , engineering , immunology , mechanical engineering , hydrazide
The cover picture shows a human affected with malaria, the disease vector Anopheles , a map from the WHO showing areas of malaria risk, and MAP‐412, an antimalarial compound developed in our group. As the map shows, regions affected by malaria include a large proportion of developing countries. Therefore, there is a need for new antimalarials that can be synthesized and supplied inexpensively. Prepared in just two steps from an inexpensive starting material, isonicotinic acid, our bis‐cationic antimalarial compounds may be useful as leads for inexpensive antimalarials. For details, see the Full Paper by H. Kakuta et al. on p. 1527 ff. (Cover design by H.K.)