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A Combinatorial Approach to 2,4,6‐Trisubstituted Triazines with Potent Antimalarial Activity: Combining Conventional Synthesis and Microwave‐Assistance
Author(s) -
Melato Sergio,
Prosperi Davide,
Coghi Paolo,
Basilico Nicoletta,
Monti Diego
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700344
Subject(s) - malaria , chloroquine , combinatorial chemistry , antimalarial agent , pharmacology , toxicology , microbiology and biotechnology , medicine , chemistry , biology , immunology
Managing malaria. Malaria is responsible for two million deaths per year particularly in developing countries, therefore there is great need for the development of cost effective treatment. The synthesis of a library of trisubstituted triazines with potent antimalarial in vitro activity is reported. Among them, five products may be developed as potential leads in the search for new drugs against plasmodial chloroquine‐resistant strains.