Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non‐Natural” Natural Product with Remarkable P‐gp Modulating Activity | Zendy

Avramova Stanislava I. | Zendy; Galletti Elena | Zendy; Renzulli Michela L. | Zendy; Giorgi Gianluca | Zendy; Sgaragli Gianpietro | Zendy; Alderighi Daniela | Zendy; Ghiron Chiara | Zendy; Corelli Federico | Zendy; Radi Marco | Zendy; Botta Maurizio | Zendy

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Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non‐Natural” Natural Product with Remarkable P‐gp Modulating Activity

Author(s) -

Avramova Stanislava I.,

Galletti Elena,

Renzulli Michela L.,

Giorgi Gianluca,

Sgaragli Gianpietro,

Alderighi Daniela,

Ghiron Chiara,

Corelli Federico,

Radi Marco,

Botta Maurizio

Publication year - 2008

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200700337

Subject(s) - natural product , reversing , chemistry , combinatorial chemistry , natural (archaeology) , computer science , product (mathematics) , stereochemistry , materials science , mathematics , biology , paleontology , geometry , composite material

An efficient synthetic strategy has been developed to prepare an oxygenated analog of Taxuspine X. Macrocycle formation through Yamaguchi macrolactonization approach gave access to an original compound ( 18 ) showing remarkable P‐gp modulating activity. Further functionalization of this versatile scaffold could lead to potential anticancer and/or MDR reversing agents.

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