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Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non‐Natural” Natural Product with Remarkable P‐gp Modulating Activity
Author(s) -
Avramova Stanislava I.,
Galletti Elena,
Renzulli Michela L.,
Giorgi Gianluca,
Sgaragli Gianpietro,
Alderighi Daniela,
Ghiron Chiara,
Corelli Federico,
Radi Marco,
Botta Maurizio
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700337
Subject(s) - natural product , reversing , chemistry , combinatorial chemistry , natural (archaeology) , computer science , product (mathematics) , stereochemistry , materials science , mathematics , biology , paleontology , geometry , composite material
An efficient synthetic strategy has been developed to prepare an oxygenated analog of Taxuspine X. Macrocycle formation through Yamaguchi macrolactonization approach gave access to an original compound ( 18 ) showing remarkable P‐gp modulating activity. Further functionalization of this versatile scaffold could lead to potential anticancer and/or MDR reversing agents.