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A Dual Selective Antitumor Agent and Fluorescence Probe: the Binary BMVC–Porphyrin Photosensitizer
Author(s) -
Kang ChiChih,
Chen ChinTin,
Cho ChihChien,
Lin YuChen,
Chang ChengChung,
Chang TaChau
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700336
Subject(s) - photodynamic therapy , photosensitizer , singlet oxygen , fluorescence , cytotoxicity , porphyrin , photochemistry , chemistry , cancer cell , biophysics , materials science , oxygen , cancer , optics , in vitro , biochemistry , medicine , biology , physics , organic chemistry
Two in one : o ‐2P‐B (shown) generates singlet oxygen for photoinduced cytotoxicity that is highly selective for cancer cells without damaging normal cells. The required excitation wavelength is very well suited for tissue penetration in photodynamic therapy (PDT). The excellent contrast in cellular imaging of o ‐2B‐P can be applied to monitor the pathway of PDT and serve as a cell death marker.