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Rapid Identification of a Putative Interaction between β 2 ‐Adrenoreceptor Agonists and ATF4 using a Chemical Genomics Approach
Author(s) -
Ladwa Sweta R.,
Dilly Suzanne J.,
Clark Andrew J.,
Marsh Andrew,
Taylor Paul C.
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700317
Subject(s) - genomics , computational biology , identification (biology) , agonist , transcription factor , chemistry , gene , biology , computer science , biochemistry , genome , receptor , botany
Chemical genomics . We have uncovered a specific interaction between the β 2 ‐adrenoreceptor agonist salbutamol and the DNA binding region of transcription factor ATF4 in a chemical genomics approach using phage display combined with photoimmobilisation.