N ‐Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites | Zendy

Bowyer Paul W. | Zendy; Tate Edward W. | Zendy; Leatherbarrow Robin J. | Zendy; Holder Anthony A. | Zendy; Smith Deborah F. | Zendy; Brown Katherine A. | Zendy

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N ‐Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites

Author(s) -

Bowyer Paul W.,

Tate Edward W.,

Leatherbarrow Robin J.,

Holder Anthony A.,

Smith Deborah F.,

Brown Katherine A.

Publication year - 2008

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200700301

Subject(s) - peptidomimetic , drug , drug discovery , parasite hosting , drug target , drug development , biology , antiparasitic agent , biochemistry , chemistry , computational biology , pharmacology , peptide , world wide web , computer science

Parasite specific : The inhibition of myristoyl‐CoA:protein N ‐myristoyltransferase (NMT) can lead to parasite death in culture. Herein we review recent work that supports the suitability of NMT as a parasite‐specific drug target. The example shown illustrates the peptidomimetic compound 2 , which is more stable, yet retains the Ser and Lys functional groups of compound 1 that are necessary for NMT inhibition.

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