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N ‐Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites
Author(s) -
Bowyer Paul W.,
Tate Edward W.,
Leatherbarrow Robin J.,
Holder Anthony A.,
Smith Deborah F.,
Brown Katherine A.
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700301
Subject(s) - peptidomimetic , drug , drug discovery , parasite hosting , drug target , drug development , biology , antiparasitic agent , biochemistry , chemistry , computational biology , pharmacology , peptide , world wide web , computer science
Parasite specific : The inhibition of myristoyl‐CoA:protein N ‐myristoyltransferase (NMT) can lead to parasite death in culture. Herein we review recent work that supports the suitability of NMT as a parasite‐specific drug target. The example shown illustrates the peptidomimetic compound 2 , which is more stable, yet retains the Ser and Lys functional groups of compound 1 that are necessary for NMT inhibition.