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Small Interfering RNA‐Mediated Silencing of Glutathione‐ S ‐Transferase A1 Sensitizes Hepatic Carcinoma Cells to Photodynamic Therapy with Pentaphyrins
Author(s) -
Rapozzi Valentina,
Lombardo Cinzia,
Cogoi Susanna,
Comuzzi Clara,
Xodo Luigi
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700273
Subject(s) - photodynamic therapy , gene silencing , small interfering rna , reactive oxygen species , oxidative stress , cancer research , chemistry , apoptosis , glutathione , genetic enhancement , rna , biology , gene , biochemistry , enzyme , organic chemistry
Photodynamic therapy (PDT) uses nontoxic photosensitizers and visible light to produce reactive oxygen species that kill malignant cells by apoptosis or necrosis. Silencing the antioxidant GSTA1‐1 gene by siRNA sensitizes hepatic HepG2 cells to PDT with pentaphyrins. The study is a proof‐of‐concept for combining PDT with antigene molecules that decrease cellular response to oxidative stress.