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Cell Specific Aptamer–Photosensitizer Conjugates as a Molecular Tool in Photodynamic Therapy
Author(s) -
Mallikaratchy Prabodhika,
Tang Zhiwen,
Tan Weihong
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700260
Subject(s) - photosensitizer , aptamer , photodynamic therapy , tumor cells , chemistry , computational biology , computer science , cell , nanotechnology , cancer research , biology , biochemistry , microbiology and biotechnology , materials science , organic chemistry
Photodynamic therapy for tumors . This paper describes the application of a molecular construct of a photosensitizer and an aptamer for phototherapeutically targeting tumor cells. Coupled with the advantages of the cell‐SELEX in generating multiple effective aptamers for diseased cell recognition, we will be able to develop highly efficient photosensitizer‐based therapeutic reagents for clinical applications.