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In vitro Effects of Plasmodium falciparum Dihydrofolate Reductase Inhibitors on Normal and Cancer Cell Proliferation
Author(s) -
Rossi Tiziana,
Coppi Andrea,
Bruni Elisa,
Sgobba Miriam,
Degliesposti Gianluca,
Rastelli Giulio
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700257
Subject(s) - dihydrofolate reductase , plasmodium falciparum , vero cell , in vitro , cytotoxicity , biology , enzyme , cell growth , reductase , cancer cell , apoptosis , cancer research , cancer , biochemistry , malaria , immunology , genetics
Toxicological evaluations were performed on two novel Plasmodium falciparum dihydrofolate reductase inhibitors and other known antimalarial drugs. Cytotoxicity tests were performed on Vero and MCF‐7 cells and apoptotic and/or proliferative markers p21 and p53 and A, B1, D1, and D2 cyclines. The results are discussed and show that this molecule can be considered an interesting new candidate for further development.