Premium
Medicinal Chemistry Aspects of Drug Targets in Sphingolipid Metabolism
Author(s) -
Nussbaumer Peter
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700252
Subject(s) - sphingolipid , ceramide , computational biology , chemistry , drug discovery , biochemistry , pharmacology , biology , apoptosis
Solving the sphinx . The sphingolipid ceramide and its metabolites are important signalling mediators, and a number of hypotheses for therapeutic opportunities in the sphingolipid field have emerged. The focus of this review is on enzyme targets in sphingolipid metabolism addressing target validation, specific issues, and available tool compounds.