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Vitamin B 12 as a Carrier for the Oral Delivery of Insulin
Author(s) -
Petrus Amanda K.,
Vortherms Anthony R.,
Fairchild Timothy J.,
Doyle Robert P.
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700239
Subject(s) - insulin , glycemic , insulin delivery , diabetes mellitus , oral administration , vitamin b12 , medicine , oral route , pharmacology , endocrinology , type 1 diabetes
The noninvasive delivery of insulin continues to be a major goal for the treatment of diabetes mellitus. Oral–enteric administration would make insulin delivery easier and more effective, as higher patient compliance and improved glycemic control are likely; yet the oral–enteric pathway has been unfeasible owing to insulin's susceptibility to proteolytic degradation and inefficient enteric uptake. Herein we show that a noninvasive oral delivery route for insulin is possible through the vitamin B 12 uptake pathway. In diabetic rat models, insulin–B 12 conjugates can significantly lower blood glucose levels when administered orally.