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Sensitive, Selective, and Irreversible Inhibition of Cyclooxygenase‐2 Activity by Copper
Author(s) -
Nagano Seiichi,
Bush Ashley I.
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700217
Subject(s) - cyclooxygenase , copper , chemistry , prostaglandin e2 , prostaglandin , prostaglandin e , metal , pharmacology , medicine , biochemistry , enzyme , organic chemistry
Copper bracelet . We analyzed prostaglandin E 2 (PGE 2 ) production by cyclooxygenase 2 (COX‐2) after exposure to biometals. Cu 2+ was the only metal ion that decreased PGE 2 production. These effects may explain the anti‐inflammatory benefits of Cu 2+ and the Cu 2+ –indomethacin complex reported previously.