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Design, Synthesis, and Biological Evaluation of Caprolactam‐Modified Bengamide Analogues
Author(s) -
Liu Gang,
Ma YiMing,
Tai WanYi,
Xie ChuanMing,
Li YuLin,
Li Jia,
Nan FaJun
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700214
Subject(s) - caprolactam , combinatorial chemistry , class (philosophy) , chemistry , stereochemistry , organic chemistry , computational biology , biochemical engineering , biology , computer science , artificial intelligence , engineering
A series of potent, water‐soluble N‐substituted bengamide analogues were discovered through diverse derivatives of the caprolactam unit of bengamide. Important SAR information was also gathered, and is different from previously reported SARs of this compound class. We therefore present a new view of bengamide natural products.