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Light‐Directed Activation of Human T‐Cells
Author(s) -
Self Colin H.,
Self Alexander C.,
Smith Jacqueline A.,
Self David J.,
Thompson Stephen
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700200
Subject(s) - bispecific antibody , cytotoxic t cell , antibody , chemistry , cd3 , computational biology , computer science , biochemistry , microbiology and biotechnology , biology , immunology , antigen , monoclonal antibody , in vitro , cd8
Anti‐human CD3 antibodies are rendered inert with a coating of photolabile 2‐nitrobenzyl groups until their activity is restored by irradiation with UVA light, at which point the antibodies are free to bind and activate T‐cells. Such antibodies should enable the regulation of cytotoxic T‐cell activity at required times and locations in the body. This would have widespread medical application, particularly in the treatment of cancer.