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CMP‐Pseudaminic Acid is a Natural Potent Inhibitor of PseB, the First Enzyme of the Pseudaminic Acid Pathway in Campylobacter jejuni and Helicobacter pylori
Author(s) -
McNally David J.,
Schoenhofen Ian C.,
Houliston R. Scott,
Khieu Nam H.,
Whitfield Dennis M.,
Logan Susan M.,
Jarrell Harold C.,
Brisson JeanRobert
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700170
Subject(s) - campylobacter jejuni , helicobacter pylori , microbiology and biotechnology , enzyme , flagellum , virulence , campylobacter , helicobacter , chemistry , bacteria , biology , biochemistry , gene , genetics
Deadly decorations . Campylobacter jejuni and Helicobacter pylori decorate their flagella, which are essential for virulence, with pseudaminic acid (Pse). Pse production is feedback‐regulated in the bacterial cell by CMP‐pseudaminic acid, a potent inhibitor of PseB, the first enzyme of the Pse pathway. Herein, STD NMR was used to map binding epitopes for PseB and to characterize the interaction between PseB and CMP‐Pse.