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Atovaquone‐Statine “Double‐Drugs” with High Antiplasmodial Activity
Author(s) -
Romeo Sergio,
Parapini Silvia,
Dell'Agli Mario,
Vaiadia,
Magrone Pietro,
Galli Germana,
Sparatore Anna,
Taramelli Donatella,
Bosisio Enrica
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700166
Subject(s) - atovaquone , malaria , plasmodium falciparum , unavailability , drug resistance , drug , pharmacology , drug development , new drug application , biology , medicine , immunology , microbiology and biotechnology , engineering , reliability engineering
Combining chemicals . Malaria is one of the most widespread parasitic infections in the world, however, the unavailability of a vaccine and the spread and intensification of drug resistance over the past 15–20 years have led to a dramatic decline in the efficacy of the most affordable antimalarial drugs. Herein, the development of “double‐drugs” to tackle inhibition of P. falciparum growth is discussed.