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The Trifluoroethylamine Function as Peptide Bond Replacement
Author(s) -
Sani Monica,
Volonterio Alessandro,
Zanda Matteo
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700156
Subject(s) - peptide , stereocenter , peptide bond , chemistry , tetrahedron , stereochemistry , bond , function (biology) , crystallography , biochemistry , biology , enantioselective synthesis , catalysis , genetics , finance , economics
3D instead of 2D . That's the main difference between the tetrahedral stereogenic trifluoroethylamine function and the planar peptide bond. This property, together with other remarkable features such as high metabolic stability and low basicity, turns out to be of great importance to allow trifluoroethylamines to be excellent peptide bond replacements.