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Biologically Stable 2‐5A Analogues containing 3′‐ O ,4′‐ C ‐bridged Adenosine as Potent RNase L Agonists
Author(s) -
Morita Koji,
Kaneko Masakatsu,
Obika Satoshi,
Imanishi Takeshi,
Kitade Yukio,
Koizumi Makoto
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700150
Subject(s) - rnase p , chemistry , interferon , rna , adenosine , biochemistry , biological activity , biology , stereochemistry , in vitro , virology , gene
2′,5′‐Oligoadenylate 5′‐triphosphate , referred to as 2‐5A, plays an important role in an interferon‐regulated RNA degradation pathway with antiviral, growth‐inhibitory, and apoptotic activities in mammalian cells. However, its short half‐life limits its therapeutic usefulness. Herein, we describe 2‐5 A analogues synthesized to be more biologically stable and therefore may be developed as chemotherapeutics for viral diseases and cancer.