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Novel Inhibitors of Checkpoint Kinase 1
Author(s) -
Arrington Kenneth L.,
Dudkin Vadim Y.
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700131
Subject(s) - kinase , chek1 , computational biology , chemistry , cancer research , medicine , biology , cell cycle checkpoint , biochemistry , cell cycle , cell
Inhibition of Chk1 kinase has garnered attention as a possible complement to DNA‐damaging chemotherapeutic agents, widening their therapeutic window. As a result, several distinct classes of Chk1 inhibitors have been recently identified with selected compound advancing to clinical trials stage. This review focuses on the challenges and recent progress achieved in this area from a medicinal chemistry perspective.