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Ferrocene Conjugates of Chloroquine and other Antimalarials: the Development of Ferroquine, a New Antimalarial
Author(s) -
Dive Daniel,
Biot Christophe
Publication year - 2008
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700127
Subject(s) - antimalarial agent , drug discovery , moiety , chloroquine , chemistry , mechanism of action , malaria , pharmacology , combinatorial chemistry , computational biology , biology , stereochemistry , biochemistry , in vitro , immunology
A convenient approach to antimalarial drug discovery is the use of the organic scaffold of a known antimalarial drug and an organometallic moiety to alter its unwanted properties and/or to optimize its initial effects. This minireview focuses mainly on the discovery of ferroquine, which has emerged from a collaborative French discovery project, and efforts to understand its mechanism of action and resistance.