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Co‐Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle–Aptamer Bioconjugates
Author(s) -
Zhang Liangfang,
RadovicMoreno Aleksandar F.,
Alexis Frank,
Gu Frank X.,
Basto Pamela A.,
Bagalkot Vaishali,
Jon Sangyong,
Langer Robert S.,
Farokhzad Omid C.
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700121
Subject(s) - aptamer , nanoparticle , chemistry , drug delivery , nanotechnology , combinatorial chemistry , materials science , biology , microbiology and biotechnology
Herein we report a novel targeted drug delivery system consisting of nanoparticle–aptamer bioconjugates, which can carry both hydrophobic and hydrophilic chemotherapeutic drugs simultaneously, and deliver them selectively in a targeted and temporally distinct manner. This work provides a robust platform for targeted co‐delivery of chemotherapeutic agents with the hope of both leveraging the synergistic effects of multiple drugs and also potentially suppressing the likelihood of drug resistance by the treated tissues.