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Rapid Synthesis of Iminosugar Derivatives for Cell‐Based In Situ Screening: Discovery of “Hit” Compounds with Anticancer Activity
Author(s) -
Zhang Lei,
Sun Fang,
Li Yingxia,
Sun Xue,
Liu Xiaomin,
Huang Yingshen,
Zhang LiHe,
Ye XinShan,
Xiao Junjun
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700120
Subject(s) - iminosugar , drug discovery , in situ , chemistry , computational biology , drug , combinatorial chemistry , pharmacology , nanotechnology , medicine , biology , biochemistry , materials science , enzyme , organic chemistry
Effective and efficacious drug screening methods are imperative in the drug discovery process. A library has been constructed efficiently and followed by in situ cell‐based screening without product purification. This method led to discovery of several iminosugar derivatives with anticancer activity.