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Hydrocarbon‐Stapled Helices: A Novel Approach for Blocking Protein‐Protein Interactions
Author(s) -
Wilder Paul T.,
Charpentier Thomas H.,
Weber David J.
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700102
Subject(s) - blocking (statistics) , peptide , protein–protein interaction , chemistry , computational biology , nanotechnology , biophysics , computer science , materials science , biochemistry , biology , computer network
Stapling proteins . Modulating protein–protein interfaces for therapeutic intervention has long been a vision of the research and pharmaceutical community. In a recent paper published by Verdine and co‐workers, they developed and implemented a new technique termed “peptide stapling” and have applied it to inhibiting the Hdm2–p53 interaction. Herein, the implications of this work are discussed.