Importance of Interaction between C1 Domain and Lipids in Protein Kinase Cα Activation: Hydrophobic Side Chain Direction in Isobenzofuranone Ligands Controls Enzyme Activation Level | Zendy

Hirai Go | Zendy; Shimizu Tadashi | Zendy; Watanabe Toru | Zendy; Ogoshi Yosuke | Zendy; Ohkubo Megumi | Zendy; Sodeoka Mikiko | Zendy

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Importance of Interaction between C1 Domain and Lipids in Protein Kinase Cα Activation: Hydrophobic Side Chain Direction in Isobenzofuranone Ligands Controls Enzyme Activation Level

Author(s) -

Hirai Go,

Shimizu Tadashi,

Watanabe Toru,

Ogoshi Yosuke,

Ohkubo Megumi,

Sodeoka Mikiko

Publication year - 2007

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200700080

Subject(s) - side chain , substituent , chemistry , alkyl , enzyme , domain (mathematical analysis) , protein–protein interaction , stereochemistry , biochemistry , organic chemistry , polymer , mathematical analysis , mathematics

Substituent direction is important : Type A–D isobenzofuranone derivatives were synthesized with differently directed hydrophobic alkyl side chains. These ligands bind in a similar conformation to protein kinase Cα but have contrasting activation abilities, possibly owing to different interaction of the side chain with the membrane lipid.

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