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The Construction of a Functional Photoactivatable Cancer Targeting Bispecific Antibody Conjugate
Author(s) -
Thompson Stephen,
Fawcett MarieClaude,
Self Colin H
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700078
Subject(s) - conjugate , antibody , bispecific antibody , chemistry , inert , cancer research , enzyme , combinatorial chemistry , cancer , biochemistry , immunology , biology , monoclonal antibody , organic chemistry , mathematics , genetics , mathematical analysis
Masked Invader : we constructed a “cloaked” bispecific antibody conjugate in which only one antibody is initially biologically active. The other antibody is rendered inert with a coating of photolabile 2‐nitrobenzyl groups until its activity is restored on irradiation with UV‐A light. Such activatable conjugates could be used to target enzymes and drugs to tumours whilst minimising side effects in the rest of the body.