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Chemical Medicine: Novel 10‐Substituted Cytisine Derivatives with Increased Selectivity for α4β2 Nicotinic Acetylcholine Receptors
Author(s) -
Kozikowski Alan P.,
Chellappan Sheela K.,
Xiao Yingxian,
Bajjuri Krishna Mohan,
Yuan Hongbin,
Kellar Kenneth J.,
Petukhov Pavel A.
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700073
Subject(s) - cytisine , nicotinic agonist , nicotine , acetylcholine receptor , acetylcholine , pharmacology , chemistry , alpha 4 beta 2 nicotinic receptor , receptor , ganglion type nicotinic receptor , nicotinic acetylcholine receptor , addiction , neuroscience , medicine , biochemistry , biology
Neuronal nicotinic acetylcholine receptors are widely distributed in the central and peripheral nervous systems. Several lines of evidence suggest that the α4β2 nAChRs mediate addiction to nicotine in tobacco smoking. Novel 10‐substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors were synthesized and may be of use in smoking cessation.