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Oxime and Oxime Ether Derivatives of 1,4‐Benzothiazine Related to Oxiconazole
Author(s) -
Milanese Lara,
Giacchè Nicola,
Schiaffella Fausto,
Vecchiarelli Anna,
Macchiarulo Antonio,
Fringuelli Renata
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700066
Subject(s) - benzothiazine , oxime , moiety , chemistry , ether , candida albicans , docking (animal) , stereochemistry , combinatorial chemistry , organic chemistry , biology , medicine , genetics , nursing
The synthesis, in vitro antifungal activity, and molecular docking experiments of some oxime and oxime ether derivatives of azole 1,4‐benzothiazine are reported herein, with the aim of evaluating the influence of a partially constrained scaffold that is structurally related to Oxiconazole and bearing the 1,4‐benzothiazine moiety, on the inhibition of Candida albicans CYP51.