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Aminocyclitols as Pharmacological Chaperones for Glucocerebrosidase, a Defective Enzyme in Gaucher Disease
Author(s) -
EgidoGabás Meritxell,
Canals Daniel,
Casas Josefina,
Llebaria Amadeu,
Delgado Antonio
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700061
Subject(s) - glucocerebrosidase , gaucher's disease , enzyme , glucocerebroside , disease , enzyme deficiency , biochemistry , medicine , chemistry
New therapeutic strategies against sphingolipidoses: a series of aminocyclitols described herein represent new structural types of compounds with promising chaperone‐like properties on GlcCerase, a defective enzyme associated with Gaucher disease.