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Pyridin‐2(1 H )‐ones: A Promising Class of HIV‐1 Non‐nucleoside Reverse Transcriptase Inhibitors
Author(s) -
MedinaFranco José Luis,
MartínezMayorga Karina,
JuárezGordiano Cecilia,
Castillo Rafael
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700054
Subject(s) - reverse transcriptase , docking (animal) , human immunodeficiency virus (hiv) , nucleoside reverse transcriptase inhibitor , nucleoside , quantitative structure–activity relationship , computational biology , chemistry , nucleoside analogue , combinatorial chemistry , stereochemistry , virology , biology , medicine , biochemistry , rna , nursing , gene
The HIV‐1 reverse transcriptase (RT) is an attractive target in the treatment of AIDS. This minireview focuses on the advances in the development of non‐nucleoside RT inhibitors of the pyridin‐2(1 H )‐one class. Representative molecules, covering several subclasses are presented. Computational studies, including automated docking and QSAR, are also discussed.