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Angeli's Salt (Na 2 N 2 O 3 ) is a Precursor of HNO and NO: a Voltammetric Study of the Reactive Intermediates Released by Angeli's Salt Decomposition
Author(s) -
Amatore Christian,
Arbault Stéphane,
Ducrocq Claire,
Hu Shenghua,
Tapsoba Issa
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200700016
Subject(s) - chemistry , peroxynitrite , salt (chemistry) , nitrite , inorganic chemistry , decomposition , cyclic voltammetry , nitric oxide , oxygen , electrochemistry , nuclear chemistry , electrode , organic chemistry , superoxide , nitrate , enzyme
Under physiological conditions, it is usually accepted that the aerobic decomposition of Angeli's salt produces nitrite (NO 2 − ) and nitroxyl (HNO), which dimerizes and leads to N 2 O. No consensus has yet been established on the formation of nitric oxide (NO) and/or peroxynitrite (ONOO − ) by Angeli's salt. Because this salt has recently been shown to have pharmacological properties for the treatment of cardiovascular diseases, identification of its follow‐up reactive intermediates is of increasing importance. In this work, we investigated the decomposition mechanism of Angeli's salt by voltammetry performed at platinized carbon fiber microelectrodes. By following the decomposition process of Angeli's salt, we showed that the mechanism depends on the experimental conditions. Under aerobic neutral and slightly alkaline conditions, the formation of HNO, NO 2 − , but also of nitric oxide NO was demonstrated. In strongly alkaline buffer (pH>10), we observed the formation of peroxynitrite ONOO − in the presence of oxygen. These electrochemical results are supported by comparison with UV spectrophotometry data.