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Cover Picture: Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs (ChemMedChem 2/2006)
Author(s) -
Rondeau JeanMichel,
Bitsch Francis,
Bourgier Emmanuelle,
Geiser Martin,
Hemmig Rene,
Kroemer Markus,
Lehmann Sylvie,
Ramage Paul,
Rieffel Sebastien,
Strauss André,
Green Jonathan R.,
Jahnke Wolfgang
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200690003
Subject(s) - bisphosphonate , zoledronic acid , farnesyl pyrophosphate , cancer imaging , chemistry , in vivo , cancer research , osteoporosis , cover (algebra) , medicine , pathology , biochemistry , biology , cancer , enzyme , atp synthase , mechanical engineering , microbiology and biotechnology , engineering
The cover picture shows micro computer tomography images that demonstrate the effect of zoledronate in the prevention of the tumor osteolytic response caused by local injection of human 4T1 mammary carcinoma cells into the tibia of nude mice. The circular arrangement shows interpolations between structural snapshots of farnesyl pyrophosphate synthase (FPPS), the molecular target of zoledronate and other bisphosphonates, upon inhibition by zoledronate and further complexation by IPP. It illustrates the structural basis for bisphosphonate treatment of bone metastasis, Paget's disease, osteoporosis, and other diseases. (Bone images courtesy of Dr. Jürg A. Gasser, Novartis Pharma AG). For more details, see the full paper by J.‐M. Rondeau, W. Jahnke, et al. on p. 267 ff.