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Cover Picture: Molecular Design and Chemical Synthesis of a Highly Potent Epothilone (ChemMedChem 1/2006)
Author(s) -
Nicolaou K. C.,
Pratt Benjamin A.,
Arseniyadis Stellios,
Wartmann Markus,
O'Brate Aurora,
Giannakakou Paraskevi
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200690000
Subject(s) - epothilones , epothilone , tubulin , microtubule , ixabepilone , chemistry , stereochemistry , computational biology , biology , cancer , microbiology and biotechnology , genetics , metastatic breast cancer , breast cancer
The cover picture shows a potent epothilone derivative with a schematized tubulin microtubule in the background. Epothilones exert their antitumor activity through the stabilization of microtubules by binding with tubulin; cell division stops if microtubules cannot disassemble properly. The structure shown here is the most potent epothilone reported to date. It is more potent than epothilone B in a wide range of cancer cell types, and shows excellent promise against taxol‐ and epothilone A‐resistant cell lines. For more details, see the communication by K. C. Nicolaou et al. on p. 41 ff.