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Unique Composite Active Site of the Hepatitis C Virus NS2‐3 Protease: a New Opportunity for Antiviral Drug Design
Author(s) -
Suo Zucai,
Abdullah Mohd Amir F.
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600285
Subject(s) - active site , protease , hepatitis c virus , virology , ns3 , drug , virus , ns2 3 protease , hepatitis , medicine , biology , chemistry , enzyme , pharmacology , biochemistry
The crystal structure of the catalytic domain of hepatitis C virus NS2‐3 protease reveals a unique composite active site. Information from the structure may lead to the design of new antiviral drugs to control liver disease.