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Cis ‐Stilbene Derived Furopyranones Show Potent Antiproliferative Activity by Inducing G2/M Arrest
Author(s) -
Fuhrer Cyril A.,
Grüter Eric,
Ruetz Stephan,
Häner Robert
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600284
Subject(s) - cell cycle checkpoint , chemistry , motif (music) , stereochemistry , bicyclic molecule , computational biology , cell cycle , apoptosis , biology , biochemistry , physics , acoustics
Bicyclic furopyranones containing the cis ‐stilbene motif are described. The derivatives show antiproliferative activity in A549 and KB31 cells. The presence of the cis ‐stilbene motif is critical for biological activity. The compounds induce cell cycle arrest at the G2/M transition.