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Studies on the Uptake of Glucose Derivatives by Red Blood Cells
Author(s) -
GarcíaÁlvarez Isabel,
Garrido Leoncio,
FernándezMayoralas Alfonso
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600282
Subject(s) - glycoconjugate , glucose transporter , red blood cell , transporter , glucose uptake , conjugate , chemistry , blood–brain barrier , biochemistry , viability assay , membrane transport , cell , biology , membrane , insulin , endocrinology , central nervous system , gene , mathematical analysis , mathematics
Erythrocytes express the same glucose transporter (GLUT‐1) as is present in the blood‐brain barrier. With the aim of testing the viability of using this transport system to deliver glucosyl drug derivatives to the brain, the uptake of several dopamine–glucose conjugates and a few structurally related analogues by erythrocytes was studied with HPLC and 1 H MAS NMR spectroscopy. The results showed that slight structural changes determine the uptake of glycoconjugates by red blood cells. However, experiments in the presence of glucose transport inhibitors showed that none of the conjugates that efficiently crossed the cell membrane were transported by GLUT‐1.